期刊
DRUG AND ALCOHOL DEPENDENCE
卷 73, 期 3, 页码 289-300出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.drugalcdep.2003.11.004
关键词
drug dependence; typology; classification; multivariate; univariate
资金
- NIAAA NIH HHS [AA03510, AA13736] Funding Source: Medline
- NIDA NIH HHS [DA12849, DA12690] Funding Source: Medline
Data from a longitudinal cohort study were used to directly compare the concurrent and predictive validity of four univariate typologic approaches with a multivariate approach in subtyping drug dependence. The four univatiate typologies were based upon: (a) age-of-onset of drug abuse/dependence, (b) presence of drug abuse in first-degree relatives, (c) presence of antisocial personality disorder, and (d) sex. The multivariate typologic approach was based on indices of vulnerability, chronicity, consequences, and psychopathology, yielding the Type A/B dichotomy first demonstrated in alcohol dependence. Subtypes generated from the univariate typologies were then each compared with the multivariate typology on measures of concurrent and predictive validity, and the strength of association was compared statistically. There was evidence of significantly greater concurrent validity of the Type A/B typology compared with the univariate typologies across all the domains of validation (risk, substance use, psychopathology, personality, and overall functioning). The multivariate typology also fared better than the univariate ones in all three domains on which predictive validity was evaluated: substance use, psychopathology, and overall functioning, as well as the degree of change in several composite scores (drug, medical, legal, and psychiatric) and the global psychiatric symptom index. This direct method of comparison seemed to demonstrate the superior validity of the multivariate cluster-analytic approach over the univariate approaches to classifying subjects with drug dependence. (C) 2003 Elsevier Ireland Ltd. All rights reserved.
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