TNF-376A marks susceptibility to MS in the Spanish population -: A replication study

This study was designed as a reappraisal of the association between the TNF-376A promoter polymorphism and susceptibility to multiple sclerosis found in the Spanish population but not in other populations. With a new dataset of patients (n = 241) and control subjects ( n = 288), the association was confirmed ( p = 0.018). The authors' data suggest that this association is specific of the Spanish white ( or related) population or, alternatively, that only studies in their population have the adequate statistical power because of the higher frequency of an extended, conserved haplotype carrying the TNF-376A allele.