期刊
JOURNAL OF NEUROSCIENCE
卷 24, 期 10, 页码 2475-2480出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.4547-03.2004
关键词
prefrontal; conditioning; reward; dopamine; noradrenaline; motivation; dialysis
We trained rats to learn that an auditory stimulus predicted delivery of reward pellets in the Skinner box. After 2 d of training, we measured changes in efflux of noradrenaline (NA) and dopamine (DA) in the medial prefrontal cortex using microdialysis on the third day. Animals were subjected to a normal rewarded session and an extinction session, in which the auditory stimulus was presented alone. In the rewarded session, both NA and DA efflux were increased, but in extinction, only NA was activated. The data suggest that NA has a role in the reaction to reward-predicting stimuli, which complements that of DA.
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