期刊
JOURNAL OF MEDICINAL CHEMISTRY
卷 47, 期 6, 页码 1591-1594出版社
AMER CHEMICAL SOC
DOI: 10.1021/jm030376y
关键词
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Bile acid-derived novel amphiphilic topology was designed and synthesized in the form of steroidal dimers. These dimers were tested for antifungal and antiproliferative activity in vitro. N-1,N-3-Diethylenetriaminebis[cholic acid amide] was found to be active against C. albicans, Y. lipolytica, and B. poitrassi at nanomolar concentration and did not show any effect on cell proliferation. N-1,N-2-Ethylenediaminebis[deoxycholic acid amide] totally inhibited the growth of human oral cancer (HEp-2) and human breast cancer (MCF-7) cells.
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