期刊
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
卷 1697, 期 1-2, 页码 225-231出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbapap.2003.11.026
关键词
varicella zoster virus; herpesvirus; cyclin-dependent kinase; kinase inhibitor; purvalanol; roscovitine; cell cycle
资金
- NIAID NIH HHS [R01 AI052168] Funding Source: Medline
Herpesviruses utilize viral and cellular kinases for replication, and these mediate essential functions that are important for viral pathogenesis. Elucidating the roles of kinases in herpesvirus infections may highlight virus-host interactions that are possible targets for kinase inhibitors with antiviral activity. Varicella zoster virus (VZV) encodes two kinases that phosphorylate viral proteins involved in regulation, assembly, and virulence. VZV infection also induces the activity of host cell cyclin-dependent kinases (cdk4 and cdk2) in nondividing cells.. causing a disregulation of the cell cycle. Roscovitine and Purvalanol, kinase inhibitors that target cdks, prevent VZV replication at concentrations with few cytotoxic effects. Cdk inhibitors therefore have potential as antivirals that may extend to a broad range of viruses and have the added advantage that resistance does not arise easily. (C) 2003 Elsevier B.V. All rights reserved.
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