期刊
SCIENCE
卷 303, 期 5664, 页码 1678-1681出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1091031
关键词
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资金
- NEI NIH HHS [R37 EY002874-24S1, R37 EY002874] Funding Source: Medline
The mammalian visual cortex is organized into columns. Here, we examine cortical influences upon developing visual afferents in the cat by altering intrinsic gamma-aminobutyric acid (GABA)-mediated inhibition with benzodiazepines. Local enhancement by agonist (diazepam) infusion did not perturb visual responsiveness, but did widen column spacing. An inverse agonist (DMCM) produced the opposite effect. Thus, intracortical inhibitory circuits shape the geometry of incoming thalamic arbors, suggesting that cortical columnar architecture depends on neuronal activity.
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