期刊
BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION
卷 1677, 期 1-3, 页码 113-119出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbaexp.2003.09.018
关键词
ATP-dependent chromatin remodeling; ISWI; transcription; replication; chromosome structure
资金
- NIGMS NIH HHS [GM49883] Funding Source: Medline
ISWI functions as the ATPase subunit of multiple chromatin-remodeling complexes. These complexes use the energy of ATP hydrolysis to slide nucleosomes and increase chromatin fluidity, thereby modulating the access of transcription factors and other regulatory proteins to DNA. Here we discuss recent progress toward understanding the biological functions of ISWI, with an emphasis on its roles in transcription, chromosome organization and DNA replication. (C) 2004 Elsevier B.V.
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