期刊
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
卷 162, 期 2-3, 页码 381-386出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/s1010-6030(03)00377-0
关键词
natural compounds; diterpenes; photochemistry; grandiflorolic acid
Irradiation of grandiflorolic acid (11) at lambda = 254 nm in acetonitrile gave the two epimers 13 and 14 through a photodecarboxylation reaction of the carboxylic group on C-4. Irradiation of compound 11 in methanol at lambda = 254 nm provided the transformation of the C-20 angular methyl into a carbomethoxymethyl group. In this case, unlike compounds 13 and 14, only one of the two possible isomers (15) was obtained (equatorial methyl at C-4). A mechanistic approach of this reaction in discussed, and the role of mutual stereochemistry between C-20 methyl and C-19 carboxylic group in determining the course of the reaction is pointed out. (C) 2004 Elsevier B.V. All rights reserved.
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