期刊
ONCOGENE
卷 23, 期 11, 页码 1958-1971出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.onc.1207393
关键词
ubiquitin; E1; ubiquitin activating enzyme; SUMO; NEDD8; MoeB
资金
- NCI NIH HHS [P30CA21765] Funding Source: Medline
- NIGMS NIH HHS [R01GM69530] Funding Source: Medline
Post-translational covalent attachment of ubiquitin and ubiquitin-like proteins (ubls) has emerged as a predominant cellular regulatory mechanism, with important roles in controlling cell division, signal transduction, embryonic development, endocytic trafficking and the immune response. Ubls function by remodeling the surface of their target proteins, changing their target's half-life, enzymatic activity, protein - protein interactions, subcellular localization or other properties. At least 10 different ubiquitin-like modi. cations exist in mammals, and attachment of different ubls to a target leads to different biological consequences. Ubl-conjugation cascades are initiated by activating enzymes, which also coordinate the ubls with their downstream pathways. A number of biochemical and structural studies have provided insights into the mechanism of ubl-activating enzymes and their roles in ubl conjugation cascades.
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