Association of progesterone receptor polymorphism with recurrent abortions

Objective: The current study sought for polymorphisms within the progesterone receptor (PR) gene. Allele and genotype frequencies of patients with repeated abortions were compared to a control group. Design: All exons of the PR of 42 women with repeated abortions and 40 controls were screened for single nucleotide polymorphisms (SNP). Determination of the DNA-sequences was performed. Results: Three SNPs were detected (exon 1: G1031C Ser344Thr; exon 4: G1978T Lcu660Val, exon 5: C2310T His770His). These SNPs are linked. The more frequent wildtype (*1) allele and the rarer (*2) allele Were found in the control group and ill the Study group at different frequencies (control *1/*1: 78% *1/*2: 22%, *2/*2: 0% patient group: *1/*1: 50%, *1/*2: 43%, *2/*2: 7%). The genotypes distributions differed group: significantly from each other (P = 0.019, chi(2) = 7.879). Conclusions: The data suggest that the rarer PR allele may be associated with all increased likelihood of repeated miscarriages contributing to its multi-factorial causes. (C) 2003 Published by Elsevier Ireland Ltd.