期刊
JOURNAL OF AFFECTIVE DISORDERS
卷 186, 期 -, 页码 119-126出版社
ELSEVIER
DOI: 10.1016/j.jad.2015.06.057
关键词
Adolescence; depression; heart rate variability; time-frequency analysis
资金
- NARSAD Young Investigator Award
- Yale Interdisciplinary Research Consortium on Stress, Self-Control and Addiction Pilot project funding [1UL1RR024925-01]
- NIDA [K01 DA034125, RO1-DA-06025, DA-017863, KO5]
- Gustavus and Louise Pfeiffer Research Foundation
- CTSA Grant from the National Center for Research Resources (NCRR), a component of the National Institutes of Health (NIH) [UL1 RR024139]
- NIH Roadmap for Medical Research
Background: Work examining the link between lower heart rate variability (HRV) and depression in children and adolescents is lacking, especially in light of the physiological changes that occur during pubertal development. Method: We investigated the association between spectral measures of resting HRV and depressive symptoms among 127 children and adolescents, ages 10-17. Using spectral analysis, we evaluated (1) the association between relative high frequency (HF) HRV and depressive symptoms; (2) the predictive power of relative HF HRV for depressive symptoms in the context of relative low frequency (LF) and relative very low frequency (VLF) HRV; and (3) the relationship between relative HF, LF, and VLF band activity, age and pubertal maturation. Results: Consistent with previous work, results revealed that relative HF HRV was negatively associated with self-reported depressive symptoms. As well, relative VLF HRV was positively associated with depressive symptoms. Regression analyses revealed that relative HF HRV and relative VLF HRV significantly predicted self-report depressive symptoms while controlling for age, sex and pubertal maturation, with relative VLF HRV emerging as the strongest indicator of depressive symptoms. Developmental findings also emerged. Age and pubertal maturation were negatively associated with relative HF HRV and positively correlated with relative VLF HRV. Conclusions: Results provide support for the relationship between HRV and depression and suggest that both HF and VLF HRV are relevant to depression symptom severity. Findings also reinforce the importance of considering pubertal development when investigating HRV-depression associations in children and adolescents. Limitations: Influences on cardiac control including physical activity levels and exercise patterns could be controlled in future work. Our data speak to a depressive symptom dimension and relative spectral power HRV. Thus, we cannot make strong claims about relative spectral power HRV and clinical depression. (C) 2015 Elsevier B.V. All rights reserved.
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