Oxidative markers of Myeloperoxidase and Catalase and their diagnostic performance in bipolar disorder

Background: Recent researches suggest oxidative stress and generalized inflammatory state to be associated with bipolar I disorder (BID). Our aim is to evaluate Myeloperoxidase (MPO) and Catalase (CAT) activities in BID. Methods: 73 BID patients and 73 healthy controls were enrolled. Patients were classified into manic, depressive and euthymic state. Serum MPO and CAT were measured in both patients and controls. Results: CAT activity was significantly lower in controls than manic, depressive and euthymics (p < 0.001). MPO activity was significantly higher in controls compared to euthymics (p=0.007) and it was significantly higher in depressives compared to euthymics (p=0.023). CAT was negatively and MPO was positively correlated with disease duration in overall the patients. Positive Predictive Value was 94.5% and Negative Predictive Value was 100% above the cutoff point for CAT activity. Conclusion: MPO and CAT activities are impaired in BID, which may be associated with oxidative stress and inflammation. Published by Elsevier B.V.