Gelation rate modulation of an α-cyclodextrin and poly(ethylene glycol)-grafted hyaluronic acid solution system by inclusion complexation of a microphase-separated structure

The gelation rate of a poly(ethylene glycol)-grafted hyaluronic acid (PEG-graft-HA) solution with adding alpha-CD was investigated in term of the microphase separation between the grafted PEG and HA. The gelation rate of PEG-graft-HA exhibiting the microphase-separated structure was two times higher than that of PEG-graft-HA showing a homogeneous miscible state.