期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 14, 期 6, 页码 1491-1493出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2004.01.019
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The influence of aromatic substitution on a newly discovered class of inhibitors of dipeptidyl peptidase IV was investigated. A 10(5)-fold increase in potency was achieved by the optimization of aromatic substituents in a parallel chemistry program. The observed SAR could be explained by an X-ray structure of the protein-ligand complex. (C) 2004 Elsevier Ltd. All rights reserved.
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