期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 126, 期 11, 页码 3529-3533出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja038565t
关键词
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A simple method for the preparation of medium ring heterocycles (7-, 8-, 9-, and 10-membered) has been developed. The process employs a Cu-catalyzed coupling of beta-Iactam with an aryl bromide or iodide followed by intramolecular attack of a pendant amino group. In some instances, the intermediate beta-lactam is observable but can be converted to the aza-heterocycle by catalysis. Acetic acid was found to be superior to transition metal complexes as a catalyst for this ring-expansion process.
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