期刊
NEURON
卷 41, 期 6, 页码 915-928出版社
CELL PRESS
DOI: 10.1016/S0896-6273(04)00086-8
关键词
-
资金
- NEI NIH HHS [EY06641] Funding Source: Medline
The ability of cone photoreceptors to adapt to light is extraordinary. In this study we evaluated two biochemical processes, visual pigment phosphorylation and transducin translocation, for their ability to contribute to light adaptation in zebrafish cones. Since cytoplasmic Ca2+ regulates light adaptation, the sensitivities of these processes to both light and Ca2+ were examined. Cytoplasmic Ca2+ regulates the sites of light-stimulated phosphorylation. Unexpectedly, we found that Ca2+ also regulates the extent of phosphorylation of unbleached cone pigments. Immunocytochemical analyses revealed that neither light nor cytoplasmic Ca2+ influences the localization of transducin in zebrafish cones.
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