期刊
SCIENCE
卷 303, 期 5666, 页码 2037-2039出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1094682
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资金
- NINDS NIH HHS [5 RO1 NS023466] Funding Source: Medline
The defining morphological feature of chemical synapses is the vesicle cluster in the presynaptic nerve terminal. It has generally been assumed that vesicles closest to release sites are recruited first during nerve activity. We tested this by selectively labeling the readily releasable pool, those vesicles released first during physiological stimulation. The readily releasable vesicles were not clustered close to the presynaptic membrane but instead were dispersed almost randomly throughout the vesicle cluster. Thus, vesicles are not recruited according to proximity to release sites but are mobilized differently, perhaps by being peeled from the surface of the cluster.
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