期刊
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
卷 35, 期 1, 页码 9-19出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jpba.2004.01.001
关键词
buspirone; metabolites; doping control; photocatalysis
The photocatalytic transformation of buspirone, an analgesic anxiolytic drug, and the formation of intermediates products have been evaluated by adopting titanium dioxide as a photocatalyst. Several molecules resulting from buspirone degradation have been identified and characterized by using HPLC/MS/MS technique. The main intermediates formed in these experimental conditions agree with the major buspirone metabolites found in vivo on rats and horses: hydroxy and dihydroxy-buspirone, despyrimidinyl buspirone and 1-pyrimidinyl piperazine. This shows that the photocatalytic system could provide in the present case a useful simulation of the metabolic transformation of dopant substances. Moreover, some more oxidized species have been recognized with the photocatalytic process, and this could offer a suggestion for yet to come metabolism studies. (C) 2004 Elsevier B.V. All rights reserved.
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