期刊
NATURE REVIEWS MOLECULAR CELL BIOLOGY
卷 5, 期 4, 页码 323-329出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm1359
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Most eukaryotes stabilize the ends of their linear chromosomes with a telomerase-based system. Telomerase maintains specific repetitive sequences, which protect chromosome ends with the help of telomere-binding proteins. How did this elaborate system evolve? Here, I propose that telomere function was originally mediated by t-loops, which could have been generated by prokaryotic DNA-replication factors. These early telomeres would have required only the presence of a few repeats at chromosome ends. Telomerase could have been a later innovation with specific advantages for telomere function and regulation.
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