期刊
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
卷 378, 期 8, 页码 1929-1934出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s00216-004-2521-5
关键词
tobacco mosaic virus; quartz-crystal microbalance; molecular imprinting; atomic force microscopy (AFM)
Surface imprinting techniques on polymer-coated quartz-crystal microbalances (QCM) have been used to detect tobacco mosaic viruses (TMV) in aqueous media. Molecularly imprinted polymers (MIP), tailor-made by self organisation of monomers around a template (TMV), were generated directly on the gold electrodes. Imprinted trenches on the polymer surface mimicking the shape and surface functionality of the virus serve as recognition sites for re-adsorption after washing out of the template. The sensors are applicable to TMV detection ranging from 100 ng mL(-1) to 1 mg mL(-1) within minutes. Furthermore, direct measurements without time-consuming sample preparation are possible in complex matrices such as tobacco plant sap.
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