期刊
GROWTH HORMONE & IGF RESEARCH
卷 14, 期 2, 页码 91-96出版社
CHURCHILL LIVINGSTONE
DOI: 10.1016/j.ghir.2003.11.004
关键词
anthropometric variables; body composition; body mass index; body fat; free insulin-growth factor-1; insulin-growth factor-1; insulin-growth factor binding protein-3
The aim of this study was to investigate the GH-IGF-I axis in healthy adults and its relationship to obesity. We studied 268 subjects: 134 men and 134 women, and determined anthropometric and body composition variables. Serum total IGF-I was measured by radioimmunoassay, serum free IGF-I concentrations by enzyme linked inummosorbant assay and serum IGFBP3 concentrations by radioimmunoassay. In men, we observed a decrease in total IGF-I free IGF-I and IGFBP-3 throughout decades. In women, the body mass index and fat mass were higher throughout decades, and we observed a similar decrease to that in men in total IGF-I, free IGF-I and IGFBP3. In men with obesity, as measured by body fat, free IGF-I concentrations were lower than those without obesity; in women with obesity, total IGF-I concentrations and free IGF-I concentrations were lower than in those with obesity. These changes were observed in relationship to obesity when the subjects were adjusted for differences in age. We showed that in controls randomly selected, the GH-IGF-I axis component concentrations that decrease with increasing age are lower in obesity, especially in women, and that this decrease is related to body mass index and body fat. (C) 2003 Elsevier Ltd. All rights reserved.
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