Cost analysis of human islet transplantation for the treatment of type 1 diabetes in the Swiss-French consortium GRAGIL

OBJECTIVE - To evaluate the cost of islet transplantation in type 1 diabetic patients With a functional renal craft in a multicenter network. RESEARCH DESIGN AND METHODS - The study involved nine diabetic patients transplanted in the Swiss-French Groupe Rhone-Alpes, Rhin et Geneve pour la transplantation d llots Langerhans (GRAGIL) consortium between March 1999 and June 2000. The direct medical costs were estimated from Social Security's perspective from the inclusion of the patient to 1 year after transplantation. All cost components were computed separately and included eva uation, screeninu an candidacy, organ retrieval, islet processing, pancreas and islet transportation, hospitalization for transplantation, follow-up, medications (immunosuppressive, antidiabetic, and adjuvant drugs), and adverse events requiring hospitalization. RESULTS - During the study period, 56 pancreata were processed and 14 islet preparations were transplanted. The average cost of an islet transplantation (procedure and 1-year follow-up) was Euro77,745 (French rate, year 2000). The four main cost components were islet preparation (30% of the total cost), adverse events (24%), drugs (14%), and hospitalization (13%). CONCLUSIONS - Overall costs of islet transplantation are slightly higher than those of pancreas transplantation. The cell isolation process is a critical point; a reduction in overall cost will require more efficient ways of isolating high yields of viable islets. Costs generated by shipments within the GRAGIL network did not represent an economic burden. it can be expected that the costs will decrease with growing experience and improving technology.