期刊
JOURNAL OF FLUORINE CHEMISTRY
卷 125, 期 4, 页码 561-566出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.jfluchem.2003.11.029
关键词
2-bromo-1,1,1-trifluoroethane; 2-bromo-1,1-difluoroethylene; bromodifluorovinylzinc; Pd(0) coupling; bromodifluorovinyllithium; alpha-bromo beta,beta-difluorostyrene
A high yield room temperature preparation of the 1-bromo-2,2-difluorovinylzinc reagent [CF2=CBrZnCl] (>89%) was achieved via insitu metallation of CF3CH2Br or CF2=CHBr with LDA in presence of ZnCl2. Palladium catalyzed cross-coupling of this zinc reagent with aryl iodides provides alpha-bromo-beta,beta-trifluorostyrenes (ArCBr=CF2) in 64-86% isolated yields, in an essentially 'one-pot' procedure. (C) 2004 Elsevier B.V. All rights reserved.
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