期刊
JOURNAL OF CELLULAR BIOCHEMISTRY
卷 91, 期 5, 页码 896-903出版社
WILEY
DOI: 10.1002/jcb.20012
关键词
Ets; transcriptional regulation; ECM; cancer; invasion; metastasis; EMT; epithelium; stroma
资金
- NCI NIH HHS [R01 CA109860-04, P01 CA078582-080005, R01 CA102297, R01 CA109860, P01 CA078582, P01 CA78582] Funding Source: Medline
- NIAMS NIH HHS [R01 AR042334, R01 AR42334] Funding Source: Medline
- NIGMS NIH HHS [R01 GM57843, R01 GM057843, R01 GM057843-08] Funding Source: Medline
The Ets family consists of a large number of evolutionarily conserved transcription factors, many of which have been implicated in tumor progression. Extensive studies on this family of proteins have focused so far mainly on the biochemical properties and cellular functions of individual factors. Since most of the Ets factors can bind to the core consensus DNA sequence GGAA/T in vitro, it has been a challenge to differentiate redundant from specific functions of various Ets proteins in vivo. Recent findings, however, suggest that such apparent redundancy may in fact be a central component of a network of differentially regulated specific Ets factors, resulting in distinct biological and pathological consequences. The programmed Ets conversion appears to play a critical role during tumor progression, especially in control of cellular changes during epithelial-mesenchymal transition and metastasis. Coordination of multiple Ets gene functions also mediates interactions between tumor and stromal cells. As such, these new insights may provide a novel view of the Ets gene family as well as a focal point for studying the complex biological control involved in tumor progression. (C) 2004 Wiley-Liss, Inc.
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