期刊
CIRCULATION JOURNAL
卷 68, 期 4, 页码 396-399出版社
JAPANESE CIRCULATION SOC
DOI: 10.1253/circj.68.396
关键词
atherosclerosis; foam cells; TWEAK
The expression of TWEAK (TNFSF12) and TweakR/Fn14 was detected in regions rich in macrophage/foarn cells in atherosclerotic plaques. The role of TWEAK in monocytes in relation to atherogenesis was investigated by analyzing the cellular events induced by TWEAK in a human macrophage-like cell line, THP-1. TWEAK induced various molecular mediators of atherogenesis, such as IL-6, MCP-1, IL-8 and MMP-9, and the induction was augmented by interferon-gamma. TWEAK-induced activation of MMP-9 was mediated by activation of NF-kappaB. These results suggest that TWEAK is involved in atherosclerosis by inducing pro-inflammatory cytokines and extracellular matrix degrading enzymes, which reduce plaque stability.
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