期刊
EUROPEAN JOURNAL OF IMMUNOLOGY
卷 34, 期 4, 页码 1085-1090出版社
WILEY
DOI: 10.1002/eji.200324170
关键词
adjuvant; IL-1; CD28
类别
资金
- NIAID NIH HHS [R01-AI27998, R01-AI39614] Funding Source: Medline
- NIDDK NIH HHS [K08-DK02784-03, R01-DK061961-01A1] Funding Source: Medline
The basis of the adjuvant effect of IL-1 on the clonal expansion of Ag-specific CD4 T cells was measured in vivo using the TCR transgenic T cell adoptive transfer method. Injection of Ag plus IL-1 caused naive CD4 T cells to proliferate to a greater extent than did injection of Ag alone. The T cells had to express CD28 to experience the beneficial effect of IL-1 whereas the host had to express the type I IL-1 R, raising the possibility that IL-1's adjuvant properties were related to induction of CD28 ligands on APC. Surprisingly, however, expression of CD28 ligands on DC and B cells was not affected by IL-1. Therefore, the adjuvant properties of IL-1 depend on a basal level of CD28 signaling but cannot be explained by enhanced CD28 signaling due to CD28 ligand induction.
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