期刊
JOURNAL OF BIOENERGETICS AND BIOMEMBRANES
卷 36, 期 2, 页码 187-193出版社
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1023/B:JOBB.0000023622.66554.a6
关键词
TOM complex; VDAC channel; upregulation of Tom proteins; transcription; translation
It has been shown recently that in Saccharomyces cerevisiae mitochondria depleted of the VDAC channel (Deltapor1 mitochondria), the TOM complex channel substitutes for the VDAC channel. The additional function of the TOM complex channel is probably facilitated by the upregulation of nuclear-encoded components of the TOM complex as has been shown for Tom40 ( a major component of the channel) and Tom70 ( one of the surface receptors). Here we report that in S. cerevisiae cells the VDAC channel seems to be an important signal in the expression of the TOM complex components. S. cerevisiae cells depleted of the VDAC channel (Deltapor1 cells) contain distinctly increased levels of Tom40mRNA, and Tom70mRNA, but their synthesis and translation are affected differentially by the applied inhibitors of transcription and translation. Consequently, it may be concluded that depletion of the VDAC channel might influence differentially the expression of TOM40 and TOM70 genes.
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