期刊
JOURNAL OF VIROLOGY
卷 78, 期 8, 页码 4011-4019出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.78.8.4011-4019.2004
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资金
- NIAID NIH HHS [R01 AI033773, R01AI33773, K08AI01421] Funding Source: Medline
Understanding the early cytokine response to lentiviral infections may be critical to the design of prevention and treatment strategies. By using the feline immunodeficiency virus (FIV) model, we have documented an interleukin 10 (IL10)-dominated response in lymphoid tissue CE4(+) and CD8(+) T lymphocytes within the first 4 weeks after mucosal FIV infection. This profile coincided with the period of high tissue viral replication. By 10 weeks postinfection, tissue viral levels decreased significantly, and gamma interferon (IFNgamma) production in CD8(+) T cells had increased to restore the IL10/IFNgamma ratio to control levels. Concurrently, increased production of IL6 and viral RNA was detected in macrophages. These temporal associations of viral replication with cytokine balance in tissues suggest roles for IL10 in the permissive stage of infection and IFNgamma in the subsequent down modulation of lentiviral infection.
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