期刊
EXPERIMENTAL EYE RESEARCH
卷 78, 期 4, 页码 895-898出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.exer.2003.10.023
关键词
A2E; lipofuscin; retinal pigment epithelium
资金
- NEI NIH HHS [EY12344] Funding Source: Medline
dSeveral retinal dystrophies are associated with the accumulation of lipofuscin in the retinal pigment epithelium (RPE). The only structurally characterized component of human retinal lipofuscin is the bis-retinoid pyridinium compound A2E. We report here on the observation of a monooxygenated product of A2E in the organic soluble portion of human retinal lipofuscin and in the organic extract of bovine RPE cells that have been fed A2E and irradiated. Liquid chromatography mass spectrometry confirms that the products are identical. This is the first observation of a photoproduct of A2E in human retinal lipofuscin. (C) 2004 Elsevier Ltd. All rights reserved.
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