期刊
BIOMETALS
卷 17, 期 2, 页码 111-113出版社
KLUWER ACADEMIC PUBL
DOI: 10.1023/B:BIOM.0000018362.37471.0b
关键词
albumin; transferrin; copper ions
Serum albumin ( human, bovine) has a specific Cu(II)-ion binding site, and is proposed to act as a copper transport protein in blood plasma. Human transferrin, normally about 30% saturated with iron in vivo, has two sites/molecule capable of complexing Cu( II); one more strongly than the other ( Hirose et al. 1996). The present study shows that this binding site has a slightly stronger affinity for Cu( II) than that on the albumins. However, both human- and bovine albumin could take up part of the transferrin bound Cu( II), the second order rate constant for the reaction estimated to 12 mM(-1) min(-1) for both species. In vivo the albumin concentration is considerably higher than that of iron-free transferrin, and it seems unlikely that the latter can compete with albumin for non-ceruloplasmin cupric ions.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据