期刊
BEHAVIORAL NEUROSCIENCE
卷 118, 期 2, 页码 438-442出版社
AMER PSYCHOLOGICAL ASSOC
DOI: 10.1037/0735-7044.118.2.438
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资金
- NINDS NIH HHS [F32NS10956-03] Funding Source: Medline
Recent studies provide evidence for an interaction between a declarative memory system, dependent on the medial temporal lobe (MTL), and a habit memory system, dependent on the basal ganglia. Using functional MRI, the authors studied this interaction when I system was compromised by neurological disease. Neural activity when performing a habit-learning task was compared in normal controls and subjects with Parkinson's disease (PD). Patients with PD showed less activation in the caudate nucleus and greater activation in a region of prefrontal cortex that has been associated with explicit memory retrieval. Patients with PD also showed activation of the MTL during the weather-prediction task. These findings are consistent with an interaction between memory systems of the MTL and the striatum.
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