期刊
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
卷 8, 期 2, 页码 161-168出版社
CAROL DAVILA UNIV PRESS
DOI: 10.1111/j.1582-4934.2004.tb00271.x
关键词
calcium; cell proliferation; calcium channels; cell signaling
The progression through the cell cycle in non-transformed cells is under the strict control of extracellular signal; called mitogens, that act by eliciting complex cascades of intracellular messengers. Among them, increases in cytoso lie free calcium concentration have been long realized to play a crucial role; however, the mechanisms coupling membrane receptor activation to calcium signals are still only partially understood, as are the pathways of calcium entry in the cytosol. This article centers on the role of calcium influx from the extracellular medium in the control of proliferative processes, and reviews the current understanding of the pathways responsible for this influx and of the second messengers involved in their activation.
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