期刊
JOURNAL OF NEUROTRAUMA
卷 21, 期 4, 页码 429-440出版社
MARY ANN LIEBERT, INC
DOI: 10.1089/089771504323004575
关键词
glial reaction; human and experimental animals; inflammation; spinal cord injury; vascular responses
资金
- NINDS NIH HHS [NS38665] Funding Source: Medline
This article reviews the pathology of human spinal cord injury (SCI), focusing on potential differences between humans and experimental animals, as well as on aspects that may have mechanistic or therapeutic relevance. Importance is placed on astrocyte and microglial reactions. These cells carry out a myriad of functions and we review the evidence that supports their beneficial or detrimental effects. Likewise, vascular responses and the role of inflammation and demyelination in the mechanism of SCI are reviewed. Lastly, schwannosis is discussed, highlighting its high frequency and potential role when designing therapeutic interventions. We anticipate that a better understanding of the pathological responses in the human will be useful to investigators in their studies on the pathogenesis and therapy of SCI.
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