期刊
JOURNAL OF NEUROIMMUNOLOGY
卷 149, 期 1-2, 页码 84-89出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2003.12.015
关键词
multiple sclerosis; experimental autoimmune encephalomyelitis; cytokines; males; estrogen
资金
- NIAID NIH HHS [AI50839] Funding Source: Medline
- NINDS NIH HHS [NS45443] Funding Source: Medline
Estrogen treatment has been found to be protective in experimental autoimmune encephalomyelitis (EAE) and possibly multiple sclerosis (MS). We investigated whether the effect of estrogen treatment is gender-specific. Estrogen receptor (ER) expressions, ERalpha and ERbeta, were found to be equivalent in both genders. EAE disease severity in both females and males was decreased with estriol treatment as compared to placebo. Finally, proinflammatory cytokine production during autoantigen-specific immune responses was decreased with estriol treatment in both females and males. These data support a potential role for estriol treatment for men in addition to women with MS. (C) 2004 Elsevier B.V. All rights reserved.
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