期刊
CURRENT OPINION IN IMMUNOLOGY
卷 16, 期 2, 页码 251-255出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2004.01.007
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- NIAID NIH HHS [5-R01-AI050867] Funding Source: Medline
The survival of mature resting B cells in the periphery depends on signaling from the B-cell receptor (BCR) and the B-cell activating factor of the TNF family receptor (BAFF-R). Engagement of both receptors promotes NF-kappaB activity, which contributes to B-cell survival through different pathways. BCR signaling leads to activation of the inhibitor of NF-kappaB kinase (IKK) complex via Carma1, Bcl10 and MALT1, whereas BAFF-R engagement promotes processing of NF-kappaB2 protein p100, which is dependent on NF-kappaB-inducing kinase (NIK) and IKKalpha. Proximal signaling intermediates are potentially common to both pathways. We suggest that BCR and BAFF-R survival signaling are mutually dependent. In addition, we propose that BAFF-R signaling enhances the expression of survival genes through direct chromatin modifications in NF-kappaB target gene promoters.
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