期刊
FOOD AND CHEMICAL TOXICOLOGY
卷 42, 期 4, 页码 585-598出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.fct.2003.11.002
关键词
Artemisia dracunculus; diabetes; estragole; extract; hyperglycemia; hypoglycemia; methyl eugenol; no observed adverse effect level; Russian tarragon; safety
TARRALIN(TM) is an ethanolic extract of Artemisia dracunculus (Russian tarragon), a common medicinal and culinary herb with centuries of use. Artemisia dracunculus is a close relative of the French or cooking tarragon and contains components common to many herbs that are routinely consumed without reported adverse effects. Since safety information of Artemisia dracunculus and its extract is limited to historical use, TARRALIN(TM) was examined in a series of toxicological studies. Complete Ames analysis did not reveal any mutagenic activity either with or without metabolic activation. TARRALIN(TM) was tested in an acute limit test at 5000 mg/kg with no signs of toxicity noted. In a 14 day repeated dose oral toxicity study, rats appeared to well tolerate 1000 mg/kg/day. Subsequently, TARRALIN(TM) was tested in an oral subchronic 90-day toxicity study (rat) at doses of 10, 100 and 1000 mg/kg/day. No noteworthy signs of toxicity were noted in feeding or body weight, functional observational battery or motor activity. Gross necropsy and clinical chemistry did not reveal any effects on organ mass or blood chemistry and microscopic examinations found no lesions associated with treatment. Therefore, TARRALIN(TM) appears to be safe and non-toxic in these studies and a no-observed adverse effect level in rats is established at 1000 mg/kg/day. (C) 2003 Elsevier Ltd. All rights reserved.
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