期刊
BIOCHEMICAL SOCIETY TRANSACTIONS
卷 32, 期 -, 页码 227-230出版社
PORTLAND PRESS LTD
DOI: 10.1042/BST0320227
关键词
circular dichroism (CD); gene regulation; histone fold; histone fusion; thermostability
资金
- NIGMS NIH HHS [GM 53185] Funding Source: Medline
Structures, stability and DNA-binding properties have been established for archaeal histories from mesophiles, thermophiles and hyperthermophiles. Most archaeal histones are simply histone folds that are stabilized by dimer formation. Archaeal histones and the histone folds of the eukaryotic nucleosome core histones share a common ancestry and bind and wrap DNA similarly using conserved residues. The histone-fold residues that stabilize dimer-dimer interactions within an archaeal histone core contribute to determining archaeal histone-DNA affinity.
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