期刊
JOURNAL OF ANTIBIOTICS
卷 57, 期 4, 页码 271-279出版社
NATURE PUBLISHING GROUP
DOI: 10.7164/antibiotics.57.271
关键词
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A screening method was established to detect inhibitors of the biosynthetic pathways of aromatic amino acids and para-aminobenzoic acid, the precursor of folic acid, using an agar plate diffusion assay modified as an antagonism test. By this screening method, a family of three novel polycyclic polyketides named as abyssomicins was isolated from a marine strain of Verrucosispora. The main component abyssomicin C inhibits the pathway between chorismate and para-aminobenzoic acid and is strongly active against Gram-positive bacteria, including multi-resistant clinical isolates of Stapkylococcus aureus.
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