Reduced triclosan susceptibility in methicillin-resistant Staphylococcus epidermidis

Triclosan MIC determination showed that recent Staphylococcus aureus clinical isolates (n = 100) were highly susceptible to triclosan, with a 50% minimal inhibitory concentration (MIC50) of 0.12 mug/ml and a MIC90 of 0.25 mug/ml. Staphylococcus epidermidis isolates (n = 96) were less susceptible, with a MIC50 of 0.12 mug/ml and a MIC90 of 8 mug/ml. Decreased susceptibility to triclosan was more prevalent among methicillin-resistant S. epidermidis than among methicillin-sensitive S. epidermidis isolates.