期刊
ARCHIV DER PHARMAZIE
卷 347, 期 10, 页码 717-727出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ardp.201400199
关键词
Antiproliferative; MCF cell lines; Mitochondria-dependent cell death; Pyrazoles; Synthesis
A series of 17 analogs of 1-acetyl-4,5-dihydro(1H) pyrazoles (JP-1 to JP-17) bearing two aromatic rings at positions 3 and 5, either of which ought to be heterocyclic, were synthesized and evaluated for their anti-proliferative potential against breast cancer (MCF-7 and T-47D) and lung cancer (H-460 and A-549) cell lines for the first time. JP-1-7, -10, -11, -14, and -15 were observed to exhibit significant anti-proliferative activity against MCF-7 cells. Some notions about structure-activity relationships are reported. The investigated compounds were found to lower the intracellular reactive oxygen species in the H(2)DCFDA assay and also caused mitochondria-dependent cell death in the MCF-7 cell line, indicating a plausible mechanism of their anticancer effect.
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