期刊
ARCHIV DER PHARMAZIE
卷 346, 期 7, 页码 499-503出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ardp.201300051
关键词
Acetylcholinesterase; Alzheimer disease; Butyrylcholinesterase; Resveratrol analogs
资金
- Hans-Bockler Stiftung (Dusseldorf)
- Grunderwerkstatt - Biowissenschaften
Novel polyhydroxylated (E)-stilbenes were synthesized by Mizoroki-Heck reactions and tested for their ability to inhibit the enzymes acetyl- and butyrylcholinesterase. Several of them are good inhibitors of butyrylcholinesterase; one of them carrying an extra fluorine substituent is a 94-fold stronger inhibitor of butyrylcholinesterase than of acetylcholinesterase.
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