期刊
INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY
卷 12, 期 2, 页码 133-138出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/106689690401200206
关键词
VEGF; c-kit; nevus; melanoma
Vascular endothelial growth factor (VEGF) and C-KIT are involved in tumor progression in several human neoplasms. The aim of the present Study has been to investigate their immunohistochemical expression in melanocytic lesions. We examined 11 compound nevi, 12 dysplastic nevi, and IS melanomas. Immunostaining for VEGF was observed only in melanomas; c-kit expression was detected in melanomas (higher in radial than in vertical growth phase) and in nevi (predominantly in the junctional component). Our data indicate that assessment of VEGF expression might aid in the differential diagnosis between dystplastic nevi and melanomas. Moreover, VEGF might be a candidate for targeted therapy. The loss of c-kit expression might contribute to melanoma progression.
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