期刊
ARCHIV DER PHARMAZIE
卷 345, 期 10, 页码 767-770出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ardp.201200121
关键词
3-Nitro-2H-chromene; Cancer cell; Inhibitory activity; Synthesis; Thioredoxin reductase
资金
- National Natural Science Foundation of China [20972195, 21172270]
- Guangdong Engineering Research Center of Chiral Drugs
A series of 3-nitrochromenes were designed and synthesized. These compounds showed good inhibitory activity against thioredoxin reductase (TrxR) and the proliferation of A549 cancer cells. The structureactivity relationship analysis indicates that the 3-nitrochromene scaffold is the crucial pharmacophore for achieving good inhibitory activity. The bromo-substitutions at the 6- and 8-position of 3-nitrochromene significantly increase the inhibitory activity.
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