期刊
ARCHIV DER PHARMAZIE
卷 344, 期 7, 页码 459-465出版社
WILEY-BLACKWELL
DOI: 10.1002/ardp.201000394
关键词
Antimycobacterials; Mycobacterium tuberculosis; Thienopyrimidines
A series of novel 5,6-unsubstituted thieno-[2,3-d]-pyrimidines has been synthesized and tested for growth inhibition of Mycobacterium tuberculosis H37Rv. Of twelve compounds synthesized eleven have shown antimycobacterial activity that differs in potency. Compounds 7b, 7c, 7d, 7e, 7f, and 7g exhibited good antimycobacterial activity. MIC values of the compounds tested were comparable with pyrazinamide. Six compounds which have shown good antimycobacterial activity were also subjected for cytotoxicity studies and were found to possess poor cytotoxicity. The study indicates the definite need for focusing attention on thienopyrimidines for further lead optimization.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据