期刊
ARCHIV DER PHARMAZIE
卷 345, 期 1, 页码 73-80出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ardp.201100082
关键词
Anticancer activity; Indolin-2-one; 4-Thiazolidinone
A novel series of indolin-2-one derivatives containing the 4-thiazolidinone moiety (5a-5p) was synthesized and the cytotoxicity of these derivatives was evaluated in vitro against three human cancer cell lines (HT-29, H460 and MDA-MB-231) by standard MTT assay. Some prepared compounds exhibited significant cytotoxicity against different human cancer cell lines. Several potent compounds were further evaluated against one normal cell line (WI-38). In particular, the promising compound 5h showed remarkable cytotoxicity and selectivity against the HT-29 and H460 cancer cell lines (IC50 = 0.016 mu mol/L, 0.0037 mu mol/L, respectively).
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