Anti-inflammatory, Analgesic, Anticonvulsant and Antiparkinsonian Activities of Some Pyridine Derivatives Using 2,6-Disubstituted Isonicotinic Acid Hydrazides

A series of novel thiazolo derivatives 2-15 was synthesized by initial condensation of 2,6-dihydroxyisonicotinohydrazide 1 and 2-chloro-6-hydrazinylisonicotinohydrazide 11 with different organic reagents. The pharmacological screening showed that many of these obtained compounds have good anti-inflammatory, analgesic, anticonvulsant, and antiparkinsonian activities comparable to diclofenac potassium, Voltarene (R), Carbamazepine (R), and Benzotropene (R) as reference drugs. Initially the acute toxicity of the compounds was assayed via the determination of their LD50. The structures of newly synthesized compounds were confirmed by IR, H-1-NMR, C-13-NMR, MS spectral data and elemental analysis. The detailed synthesis, spectroscopic data, LD50 and pharmacological activities of the synthesized compounds were reported.