期刊
CYTOKINE & GROWTH FACTOR REVIEWS
卷 15, 期 2-3, 页码 87-95出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.cytogfr.2004.02.004
关键词
T1/ST2; IL-1; immune response; Th2; cytokines; TLR
Th2-associated factors such as IL-4 are involved in both the development of Th2 responses (via modulating Th2 cell differentiation) and in the effector phase of Th2 responses (via modulating macrophage activation). The IL-1 receptor-like protein ST2 (T1, Fit-1, or DER4) is expressed as a membrane-bound (ST2L) or secreted form (sST2), and has been clearly implicated as a regulator of both the development and effector phases of Th2-type responses. Here we analyze the mechanisms and therapeutic implications of the unique ability of ST2 to promote development and function of type 2 helper T cells through a positive feedback loop, as well as to act as a negative feedback modulator of macrophage pro-inflammatory function. (C) 2004 Elsevier Ltd. All rights reserved.
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