期刊
EUROPEAN JOURNAL OF IMMUNOLOGY
卷 34, 期 4, 页码 1068-1076出版社
WILEY
DOI: 10.1002/eji.200324532
关键词
CD4 T cells; Th2 cells; vitamin D; asthma; cytoskeleton rearrangement; migration
类别
The fat soluble vitamin D3 metabolite 1,25-dihydroxyvitamin D3 [1,25(OH)(2)D-3], and its nuclear receptor play an important role in regulating immune responses. While 1,25(OH)(2)D-3 is known to inhibit transcription of cytokine genes that are required for Th1 differentiation or are products of differentiated Th1 cells, its role in regulating differentiation of Th2 cells is less clear. In this study, we show that 1,25(OH)(2)D-3 has anti-inflammatory effects in an in vivo Th2-dependent asthma model. In addition, we demonstrate that 1,25(OH)(2)D-3 down-regulates the cytoskeleton rearrangement required for promoting integrin-mediated adhesion of naive and effector CD4(+) T cells. Finally, 1,25(OH)(2)D-3 inhibits chemokine-induced migration of naive cells and their homing to the lymph nodes. Thus, in addition to its regulation of cytokine transcription, 1,25(OH)(2)D-3 regulates migration of cells and thus controls the skewing of various Th subsets in the secondary lymphoid organs and inhibits Th function at sites of inflammation.
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