期刊
GENE THERAPY
卷 11, 期 8, 页码 649-657出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.gt.3302251
关键词
transcriptional regulation; inducible transcription; ligand-dependent switches
The clinical efficacy and safety as well as the application range of gene therapy will be broadened by developing systems capable of finely modulating the expression of therapeutic genes. Transgene regulation will be crucial for maintaining appropriate levels of a gene product within the therapeutic range, thus preventing toxicity. Moreover, the possibility to modulate, stop or resume transgene expression in response to disease evolution would facilitate the combination of gene therapy with more conventional therapeutic modalities. The development of ligand-dependent transcription regulatory systems is thus of great importance. Here, we summarize the most recent progress in the field.
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