期刊
JOURNAL OF INORGANIC BIOCHEMISTRY
卷 98, 期 4, 页码 649-656出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jinorgbio.2004.01.016
关键词
ascorbic acid; dehydroascorbic acid; arsenic acid; arsenic(III) complexes; dioxygen activation
Ascorbic acid in the presence of a catalytic amount of iodine reduces arsenic acid in methanol giving the arsenious acid bound to the 2-methyl hemi-ketal of dehydroascorbic acid, 5, in 1: 1 and in a more stable 2:1 5/As(III) molar ratio. Removal of the As(III) and treating the 2-methyl hemi-ketal of dehydroascorbic acid with refluxing acetonitrile affords the pure, crystalline dehydroascorbic acid dimer in good yields. Ascorbic acid also binds to As(III) of H3AsO3 in a 1: 1 and 2:1 ascorbic acid/As(III) molar ratio. The 1: 1 complex is not stable and by expulsion of H3AsO3 is transformed to the more stable 2:1 complex. The data do not permit distinguishing the 2:1 complexes between [AsL2(H2O)]H--(+) or AsL(LH)(H2O) where L is the bis deprotonated and LH is the mono deprotonated 2-methyl hemi-ketal of dehydroascorbic acid or ascorbic acid. The 2:1 ascorbic acid/As(III) complex is oxidized by dioxygen, in a solvent-dependent manner, to dehydroascorbic acid implying dioxygen activation by the bound As(III). With thiophenol the same complex gives quantitatively triphenyl trithioarsenite, As(SPh)(3). (C) 2004 Elsevier Inc. All rights reserved.
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